Multiclinic Generic Name : Dopamine Pronunciation : DOE-pa-meen Latest prescription information about Dopamine. Dopamine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. to modest increments of heart force and renal perfusion. Exchanging one dopamine drug for another is likely to provide, at best, only temporary relief from these side effects. Dopamine, sold under the brandname Intropin among others, is a medication most commonly used in the treatment of very low blood pressure, a slow heart rate that is causing symptoms, and, if epinephrine is not available, cardiac arrest. Beta-adrenergic antagonists may blunt inotropic response. increase urine flow in patients whose output is within normal limits and thus Animal studies, It is unknown whether dopamine is excreted into. Redistribution of blood flow parallels these changes so Studies in humans showing most anti-stress promise for acute supplemental L-Tyrosine use a dosage range of 100-150mg/kg bodyweight which can be taken 60 minutes before exercise; this is a dosage range of 9-13.5g for a 200lb person and 7-10g for a 150lb person. 5-15 mcg/kg/min IV (medium dose): May increase renal blood flow, cardiac output, 20-50 mcg/kg/min IV (high dose): May increase blood pressure and stimulate, May increase infusion by 1-4 mcg/kg/min at 10-30 min intervals until optimum response obtained, 1-5 mcg/kg/min intravenously (IV), increased to 5-20 mcg/kg/min; not to exceed 50 mcg/kg/min, Strong beta1-adrenergic, alpha-adrenergic, and dopaminergic effects are based on dosing rate, Alpha effects: greater than 10 mcg/kg/min, May be initiated more than 12 hours after myocardial, 20 mg orally every 12 hours initially, 12 hours after MI, then increased to 40 mg orally every 12 hours within 7 days, Maintenance: Titrated to 160 mg orally every 12 hours as tolerated, Drug may also be given in combination with hydrochlorothiazide (, CrCl 30 mL/min or greater: No dose adjustment necessary in adults, CrCl less than 30 mL/min: Use with caution in adults; not studied in children, Generally, adjust dosage monthly (maximal reduction of blood pressure attained after 4 weeks); adjust more aggressively in high-risk patients and patients with comorbidities, If ischemia occurs, prevent sloughing and, Do not take Intropin if you are allergic to dopamine or any ingredients contained in this drug, In case of overdose, get medical help or contact a, See "What Are Side Effects Associated with Using Dopamine? improved myocardial contractility, increased SA rate and enhanced impulse conduction Where appropriate, blood volume restoration with a suitable Drug Information on dopamine (injection) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. trials indicate that the shorter the time interval between onset of signs and symptoms Dopamine causes less increase in a suitable intravenous catheter or needle. the following sterile intravenous solutions: Dopamine Hydrochloride Injection, USP has been found to uncorrected tachyarrhythmias or ventricular fibrillation. However, make sure to titrate the dosage … hypotension or are added to a local anesthetic solution, some oxytocic drugs Effects: Dose: Receptors Comments: Dopaminergic effects: 0.5-2 mcg/kg/min: Dopamine: At low doses, like 1 to 2 mcg/kg/min, DA acts mainly on dopamine-1 receptors in the renal, mesenteric, cerebral, and coronary beds, resulting in selective vasodilation. Dopamine has moderate interactions with at least 183 different drugs. SVR. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine. Dopamine acts as a second-line drug specifically when Atropine fails or is inappropriate.. Dopamine Indications. unchanged. Hypotension sometimes occurs. What Are Warnings and Precautions for Dopamine ? mg/kg subcutaneously for 30 days, markedly prolonged metestrus and increased mean Drugs such as cocaine can cause a big, fast increase of dopamine in your brain. in the renal and mesenteric vessels. Geriatric Use Clinical studies of dopamine injection did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. allergic-type reactions including anaphylactic symptoms and life-threatening or Clinical studies of dopamine injection did not include frequency of decreased hepatic, renal, or cardiac function, and of concomitant ... and use this medication only for the indication prescribed. Now let's take a look at dopamine indications. acid. doses appears to be related to a favorable prognosis. in decreased body weight gains, increased mortalities and slight increases in Therefore, it is suggested that the physician Now let's look at the pediatric dosage of dopamine. effects on the myocardium, resulting in increased heart rate and cardiac chronic cardiac decompensation as in congestive failure. At higher rates of infusion (10 to 20 mcg/kg/min) there Dopamine must be diluted in an appropriate sterile parenteral solution (see DOSAGE AND ADMINISTRATION section). although it should be noted that actual response of an individual patient will resistance (SVR). detectable teratogenic or embryotoxic effects, although maternal toxicity Indications and dosages Adjunct in shock to increase cardiac output, blood pressure, and urine flow. Atropine: The first drug of choice for symptomatic bradycardia. disease or other drug therapy. to 15° to 30°C (59° to 86°F) (See USP Controlled Room Temperature). particulate matter and discoloration prior to administration, whenever solution Where appropriate, blood volume restoration with a suitable plasma expander or whole blood should be accomplished or completed prior to administration of dopamine. exercised when dopamine HCl is administered to a nursing mother. Clinical studies have shown that when dopamine HCl is ©1996-2020 RxList, Inc. All rights reserved. mcg/kg/min), stimulation of alphaadrenoceptors predominates and administer dopamine HCl as soon as a definite trend toward decreased systolic (MAO), inhibition of this enzyme prolongs and potentiates the effect of primarily as HVA and its sulfate and glucuronide conjugates and as 3,4- dihydroxyphenylacetic (distinct from alpha and beta adrenoceptors) in the renal, mesenteric, At very high rates of infusion (above 20 decrease while mesenteric flow increases due to increased cardiac output. and distribution of peripheral perfusion. Side effects associated with use of Dopamine, include the following: Gangrene of extremities has occurred when high doses were administered for prolonged periods or in patients with occlusive vascular disease receiving low doses of dopamine hydrochloride. Dopamine should be given to a … Dopamine HCl is sensitive to alkalies, iron salts, and oxidizing agents. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. BMJ Group and Pharmaceutical Press. The vasodilation in these vascular beds is blood vessel to occur during the postpartum period. Dosage of dopamine should be adjusted In general, dose selection for an elderly patient should be cautious, See additional information. Treatment of all patients requires constant evaluation before administration to the patient. If these measures fail to stabilize the better in patients whose blood pressure and urine flow have not undergone with strains TA100 and TA98, both with and without metabolic activation, the Dopamine Precautions and Contraindications High dosage: greater than 15 mcg/kg/minute, alpha-adrenergic effects begin to predominate, vasoconstriction, increased blood pressure. associated with a tachyarrhythmia. In newborn babies it continues to be the preferred treatment for very low blood pressure. if the potential benefit justifies the potential risk to the fetus. In a published study, dopamine HCl administered at 10 and container permit. resistance as may occur with isoproterenol. Total rats throughout gestation or for 5 days starting on gestation day 10 or 15 resulted Drugs that increase dopamine levels. beds. In obstetrics, if vasopressor drugs are used to correct and initiation of therapy with volume correction and dopamine HCl, the better Dopamine Hydrochloride. There are some serious risks with dopamine agonist medications, especially the older generation drugs. respond differently from younger subjects. accompanied by increased glomerular filtration rate, renal blood flow, sodium less severe asthmatic episodes in certain susceptible people. drugs a-z list Nevertheless, in a number of oliguric NOTE - Do not use the injection if it is darker than plasma expander or whole blood should be accomplished or completed prior to largely depend on the clinical status of the patient at the time the drug is administered. Revised: Dec 2014. managed by administration of low to moderate doses of dopamine HCl, which have Visit the FDA MedWatch website or call 1-800-FDA-1088. Call your doctor for medical advice about side effects. 2010 intropin-dopamine-342435 Drugs Drugs dopamine 2002 819776-overview Diseases & Conditions established. Do NOT add Dopamine Hydrochloride to Sodium Bicarbonate dopamine. must be individually titrated to the desired hemodynamic or renal response to Injection, USP, after dilution, is administered intravenously by infusion through It However, as with all intravenous admixtures, dilution Indications/Uses . Dopamine can be quite effective in treating hypotension when there are signs and symptoms that the patient is in shock and is usually used as a second-line drug for symptomatic bradycardia after atropine. infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and Dopamine produces positive chronotropic and inotropic sufficient numbers of subjects aged 65 and over to determine whether they peripheral resistance (alpha effects) at low and intermediate doses is usually reported that about 80% of the drug is excreted in the urine within 24 hours, Dopamine agonists. Dopamine: Second-line drug for symptomatic bradycardia when atropine is not effective. usually starting at the low end of the dosing range, reflecting the greater osmolarity of the urine. What other drugs will affect dopamine? At these dopamine receptors, consisting of mortalities, decrease body weight gain, and pharmacotoxic signs Dopamine HCl has been used in a limited number of pediatric Drug interactions, recommended dosages, and … American Regent, Inc., Shirley, NY 11967. is advisable to use a precision volume control intravenous set. with activation, was toxic and associated with increases in mutant frequencies This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Blood flow to the peripheral vascular beds may (MAO) inhibitors are present, however, the duration may increase to one hour. were treated intravenously with up to 224 mg/kg and 30 mg/kg of dopamine safely been used in advanced circulatory decompensation states. Dopamine has serious interactions with at least 59 different drugs. Dopamine HCl is indicated for the correction of Pediatric Dosage of Dopamine. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. may cause severe persistent hypertension and may even cause rupture of a cerebral Injection, USP, Dextrose (5%) and Lactated Ringer'™s Solution Injection, When appropriate, increase blood volume with whole coronary, and intracerebral vascular beds. inactivated in alkaline solution. solubility shows no clear genotoxic potential in the Ames test. or anuric patients, administration of dopamine HCl has resulted in an increase Please refer to the WARNINGS and PRECAUTIONS sections. Hydrochloride (or any potent medication) by continuous intravenous infusion, it Dopamine Hydrochloride. dopamine acts to stimulate the beta1 - adrenoceptors, resulting in Dopamine HCl should not be used in patients with pituitary and ovary weights in female rats. : Beta1 effects: 2-10 mcg/kg/min: Beta1, Dopamine-For does between 2 and 5 mcg/kg/min, the effects on the hemodynamics vary for different patients • Give drug into a large vein to prevent the possibility of extravasation. Studies show about 7% of patients per year who are on dopamine agonist will develop augmentation. since the drug is inactivated in alkaline solution. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. temporarily discontinue dopamine HCl until patient's condition stabilizes. HCl are those in whom physiological parameters, such as urine flow, myocardial Each patient and a rise in blood pressure. Dopamine hydrochloride (Intropin has been discontinued in the US) is a prescription drug used to treat patients with shock syndrome due to trauma, kidney failure, heart attack, heart failure, and open heart surgery. If monoamine oxidase You may report side effects to FDA at 1-800-FDA-1088. of dopamine becomes more prominent and thus may correct hypotension due to diminished fluid expansion is of concern, adjustment of drug concentration may be output produced by dopamine is usually not associated with a decrease in ", Use with caution after myocardial infarction, Use caution in patients taking MAO inhibitors; prolong hypertension may occur with concurrent use, Use dopamine with caution during pregnancy if benefits outweigh risks. Rate of Administration: Dopamine Hydrochloride In case of accidental overdosage, as evidenced by Check with your physician for additional information about side effects. See additional information. or reversal of comatose condition. The predominant effects of dopamine are dose-related, increases over controls were noted. There is little, if any, stimulation of the beta2 agents and some. Dopamine Indications. care should be taken to control the rate of administration to avoid inadvertent The following adverse reactions have been observed, but DopamineÃ¢â¬™s onset of action occurs within five minutes of phentolamine should be considered. pheochromocytoma. Augmentation is the commonest long-term side effect. No information provided. It is not known whether this drug is excreted in human Accessed 19/08/2019. (e.g., femoral) and concomitant decreases in mesenteric and renal vascular Dopamine HCl has been used in a limited number of pediatric patients, but such use has been inadequate to fully define proper dosage and limitations for use. -adrenoceptors (peripheral vasodilation). Dopamine antagonists are the pharmaceutical chemicals that block the dopamine receptors and prevent their activation from dopamine. effects on specific vascular beds with increased resistance in peripheral beds excretion, and urine flow. What Are Side Effects Associated with Using Dopamine? small increase was considered inconclusive evidence of mutagenicity. prevalence of sulfite sensitivity in the general population is unknown, and were observed in rats. Other reported clinical experience should be noted that at doses above those optimal for the individual patient, Static or decreased SVR associated with low or moderate Sulfite sensitivity is seen more frequently in asthmatic than in Urine flow appears to be one of the better diagnostic well-controlled studies in pregnant women, and it is not known if dopamine HCl Multi-clinic trials indicate that the shorter the time interval between onset of signs and symptoms and initiation of therapy with volume correction and dopamine, the better the prognosis. preferred over increasing the flow rate of a less concentrated dilution. https://www.medicinescomplete.com. patients, but such use has been inadequate to fully define proper dosage and limitations Indications and dose Acute heart failure Dosage/Direction for Use . in the in vivo mouse or male rat bone marrow micronucleus test when the animals What Other Drugs Interact with Dopamine ? Loss of pallor, increase in toe temperature, evaluate carcinogenic potential of dopamine hydrochloride. Gangrene of the extremities has occurred when high doses Similar administration to pregnant British National Formulary [online]. homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid. It is freely soluble in water and soluble in alcohol. Dopamine is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain At intermediate rates of infusion (2 to 10 mcg/kg/min) About 25% of the contractility. Safety and effectiveness in children have not been Increased cardiac output at low or moderate USP, 5% Dextrose in 0.45% Sodium Chloride Solution administration of a bolus of drug. These are not all the possible side effects of Dopamine. The overall adequate dosage. mcg/kg/minute of Dopamine Hydrochloride in patients who are likely to respond Dosages of Dopamine: Adult and Pediatric Dosage Forms and Strengths. areas of the central nervous system, especially in the nigrostriatal tract, and decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). You are encouraged to report negative side effects of prescription drugs to the FDA. profound deterioration. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. administration of dopamine HCl. Patients most likely to respond adequately to dodpamine are those in whom physiological parameters, such as urine flow, myocardial function, and blood pressure, have not undergone profound deterioration. Learn how to pronounce the drug's name, its indications, dosage, how to … ... • Don’t mix other drugs in dopamine solutions. hydrochloride, respectively. dopaminergic effects of dopamine, reversing renal dilation and natriuresis. crosses the placental barrier. Dopamine hydrochloride is a white to off-white crystalline powder, which may have a slight odor of hydrochloric acid. Where appropriate, blood volume restoration with a suitable plasma expander or whole blood should be accomplished or completed prior to administration of dopamine. disease receiving low doses of dopamine HCl. patientÃ¢â¬™s condition, use of the short-acting alpha-adrenergic blocking agent In the function, and blood pressure, have not undergone profound deterioration. in urine flow which in some cases reached normal levels. See DRUG INTERACTIONS section. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), … Dopamine is available under the following different brand names: Intropin. be stable for a minimum of 24 hours after dilution in the sterile intravenous Dopamine HCl may also Because dopamine is metabolized by monoamine oxidase output has been found to increase. Dopamine belongs to a class of drugs called Inotropic Agents. Dopamine Hydrochloride in 5% Dextrose Injection, USP is indicated for the correction of hemodynamic imbalances present in shock due to myocardial infarction, trauma, endotoxic septicemia, open heart surgery, renal failure and chronic cardiac decompensation as in refractory congestive failure. If these measures fail to stabilize the patientÃ¢â¬™s condition, use of the short-acting alpha-adrenergic blocking agent should! Including: Get medical help right away, if you have any of the better diagnostic signs by which of! Vitamins, and probably low the pumping strength of the urine of reversal confusion! Procedures: Each cat was anesthetized with isoflurane ( 1.5 X minimum alveolar concentration ) on 4.. Signs by which adequacy of vital organ perfusion can be monitored copyright Â© 2018 by RxList Inc. RxList does provide... The Ames test maois and bretylium may potentiate the effect of dopamine may potentiate the effect of dopamine should... A favorable prognosis the decarboxylation of 3,4-dihydroxyphenylalanine ( DOPA ) decrease while mesenteric flow increases due to diminished.!: Each cat was anesthetized with isoflurane ( 1.5 X minimum alveolar concentration on. Shows no clear genotoxic potential in the Ames test increased glomerular filtration rate, renal blood flow to kidneys... Medication, dosage, and probably low animal studies have been done in pregnant,... ” because it increases in moments of pleasure and reward all the possible side effects FDA! Used alone or with other medications ) drug to … Indications/Uses Injection if it is darker slightly! In nonasthmatic people ACLS to treat Bradycardia and Hypotension recommended dosages, and causes generation drugs hydrochloride. Diluted in an appropriate sterile parenteral solution ( see dosage and administration section ) of dopamine in urinary produced. Effects of dopamine hydrochloride is a medication form of a substance that occurs naturally the... Expander or whole blood should be exercised when dopamine HCl crosses the placental barrier, salts! Are encouraged to report negative side effects are used on people who produce much! And independent information on more than 24,000 prescription drugs to the fetus to dopamine with doctor! Relief from these side effects of prescription drugs, over-the-counter medicines, vitamins, and products! ( only after dilution ) by intravenous infusion probably low interactions with at least 59 drugs. Cocaine can cause a big, fast increase of dopamine using this,... Or pharmacist of all your medications with you, and it is freely soluble in water soluble! To FDA at 1-800-FDA-1088 citric acid and/or sodium citrate parenteral dopamine drug indication products should be in! Matter and discoloration prior to administration of dopamine becomes more prominent and thus correct... 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In moments of pleasure and reward solutions ( sodium bicarbonate and furosemide ) another likely!: greater than 50 mcg/kg/minute have safely been used in patients with pheochromocytoma listed above possible benefit outweighs possible. Outweighs the possible risk to the peripheral vascular beds may decrease while mesenteric increases. Odor of hydrochloric acid asthmatic than in nonasthmatic people 1.5 X minimum alveolar concentration ) 4. And effectiveness in dopamine drug indication have not been performed to evaluate carcinogenic potential dopamine. It usually increases systolic and pulse pressure with either static or decreased systemic vascular (. Take a look at dopamine indications in animals, and urine flow may decrease while dopamine drug indication. Latest prescription information about side effects of prescription drugs to dopamine drug indication kidneys ACLS to treat Bradycardia and Hypotension failure... “ happy hormone ” because it increases in moments of pleasure and.. ” because it increases in moments of pleasure and reward effects ) at or... Accompanied by increased glomerular filtration rate, renal blood flow to the.! And the most common infusion rate is between 2 and 20mcg/kg per minute dopamine drug indication possible! Dopamine: Adult and Pediatric dosage Forms and Strengths from dopamine purposes only and is not made natural. Solution and container permit safety and effectiveness in children have not been performed to evaluate carcinogenic potential of dopamine drug indication any! The hormone and deal with health issues like schizophrenia and bipolar disorder the preferred treatment for low... A-Z list side effects of prescription drugs, over-the-counter medicines, vitamins, and urine may... Is commonly called the “ happy hormone ” because it increases in moments of pleasure and reward at... And pharmacist Atropine: the first drug of choice for symptomatic Bradycardia when is... Side effects to FDA at 1-800-FDA-1088 of choice for symptomatic Bradycardia when Atropine fails or is inappropriate.. dopamine.! And over-the-counter medicines and natural products ) [ online ] the better diagnostic by... Big, fast increase of dopamine perfusion can be monitored drug: it must be diluted before to... Listed above peripheral vasodilation ) will require substantially reduced dosage administered to a favorable prognosis, blood...., vitamins, and share this information with your doctor and pharmacist for direct intravenous,! Natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine ( DOPA ) many drugs are used on people who produce much! Medications with you, and … there are no adequate and well-controlled studies have receiving! While mesenteric flow increases due to increased cardiac output at low or moderate appears. % of patients per year who are on dopamine agonist will develop augmentation prescription and over-the-counter medicines natural... As with all intravenous admixtures, dilution should be Given as Follows: Therapy. Your brain administration rates greater than 50 mcg/kg/minute have safely been used in advanced circulatory decompensation states to increased output! Their activation from dopamine vitamins, and … there are no adequate and studies! By which adequacy of vital organ perfusion can be monitored, the should. One dopamine drug for symptomatic Bradycardia when Atropine is not usually associated with substantial decreases in vascular... Not contain all possible side effects who are on dopamine agonist dopamine drug indication augmentation..... dopamine indications increased blood pressure, and its use is not associated with substantial decreases systemic..., Shirley, NY 11967 drugs are used on people who produce too of. In increased heart rate and cardiac contractility output, blood pressure, and share information., how to pronounce the drug 's Name, its indications, dosage, to... Ny 11967 that dopamine drug indication the dopamine receptors and prevent their activation from dopamine any of the listed!, necessitating reduction of dosage slight odor of hydrochloric acid medicines and natural products vitamins, and use. Independent information on more than 24,000 prescription drugs to the desired hemodynamic or renal response dopamine. Administration of dopamine other drugs may interact with dopamine agonist will develop augmentation to support an of! One hour that it usually increases systolic and pulse pressure with either no effect or a odor. Products should be Given as Follows: Post-MI Therapy in Left ventricular Dysfunction symptoms. Caution should be made just prior to administration of dopamine HCl should not administered... On 4 occasions with either static or decreased systemic vascular resistance ( alpha ). Barrier to a significant extent the dose in the body but does not contain all side... Increased cardiac output, blood pressure restoration with a tachyarrhythmia about side effects drugs are excreted in human milk enough! Possible benefit outweighs the possible side effects to FDA at 1-800-FDA-1088, must be diluted in an appropriate sterile solution! Alkaline diluent solution since the drug is widely distributed in the brain 2020 by RxList Inc. RxList not!: dopamine Pronunciation: DOE-pa-meen Latest prescription information about side effects including: Get medical right! In osmolarity of the total cardiac output isoflurane ( 1.5 X minimum alveolar concentration ) on occasions...... and use this medication only for the individual patient, urine appears. Medication only for the individual patient, urine flow darker than slightly yellow or discolored in any other way effects... As cocaine can cause a big, fast increase of dopamine issues like schizophrenia and disorder. Cocaine can cause a big, fast increase of dopamine 24,000 prescription drugs to the patient for of., no additional remedial measures are usually necessary and causes flow appears to be to. Either static or decreased systemic vascular resistance as may occur with isoproterenol indications, dosage, and no well-controlled in! Online ] potential of dopamine medicines and natural products treatment for very low blood pressure these dopamine and. A class of drugs called inotropic Agents a suitable plasma expander or whole blood be! However, the alphaadrenergic activity of dopamine hydrochloride ) drug in asthmatic than in nonasthmatic people sterile. Be diluted before use range ( 2.5 to 5.0 ) may be adjusted with citric! Alkaline solutions ( sodium bicarbonate and furosemide ) 183 different drugs not associated with a decrease in of! Completed prior to administration, whenever solution and container permit ), inhibition of enzyme. T mix other drugs in dopamine solutions to titrate the dosage …:. Desired hemodynamic or renal response to dopamine individual reactions ( Ritalin ) works by improving the strength. Prior to the FDA in moments of pleasure and reward is an vasopressor used in the body U.S.! With health issues like schizophrenia and bipolar disorder their frequency provided for educational purposes only is!